Endocrine Abstracts

Secondary endocrine hypertension affects around 10% of all hypertensive population, most frequently primary aldosteronism (PA). Less frequent forms of adrenal hypertension include pheochromocytomas and other causes of mineralocorticoid excess than PA, featuring suppressed renin without excess of aldosterone. Featuring. We present a 29-year-old woman with difficult to control hypertension diagnosed two years before and poor response to ACEI and ARA II treatment. She was referre...

Introduction: Subclinical hypercortisolism (SH), a condition of biochemical cortisol excess without the classical signs or symptoms of overt hypercortisolism, is thought to be present in the 5–30% of patients with incidentally discovered adrenal mass (adrenal incidentalomas). Some evidence suggest that this condition may lead to long-term consequences of cortisol excess, but indication and potential benefits of adrenalectomy in this state are still in doubt. We analyse a ...

Introduction: CCHD comprises a number of different congenital heart defects associated with elevated pulmonary artery pressure and pulmonary vascular resistance, resulting in a reversed or bidirectional shunt (Eisenmenger syndrome). These entities develop systemic hypoxia. Pheochromocytoma and paraganglioma (PHEO/PG) are neuroendocrine tumours. Several inheritance genetic alterations have been reported in PHEO/PG syndromes. A pathogenic association between these entities is pr...

In our centre, thyroid core-biopsy (CB) has replaced fine needle aspiration biopsy (FNAB) in the study of thyroid nodules because its better accuracy. International guidelines recommend repeating the FNA in cases of inadequate or insufficient first specimen, but nothing is published about the case in failed CB.Objective: To study the differences between nodules with inadequate and diagnostic thyroid Core Biopsy and the accuracy of repeating a CB after a ...

Background: The cortisol suppression test with 1 mg dexamethasone (DST) is a screening test for hypercortisolism with high sensitivity (95%) for serum cortisol cut-off <1.8 μg/dl. However, cortisol tests may give false positive in patients with severe obesity (SO). On the other hand, bariatric surgery (BS) is the most effective treatment for SO, and the operated population is growing. At present there is no reliable data regarding the impact of BS on DST results in pa...

Background: PHPT is the leading cause of hypercalcemia in outpatients. Its clinical presentation varies from asymptomatic forms to renal or bone complications. The only curative treatment is surgical resection, and delayed diagnosis can lead to serious morbidity.Objective: Identify the presence of PHPT at least one year prior to referral to endocrinology consultation. Secondly, determine whether diagnostic delay leads to increased complications.<p cl...

Introduction: Maternal clinical thyroid disorders can cause reproductive complications. However, the effects of mild thyroid dysfunction are controversial. The impact of SH and thyroid autoimmunity on miscarriages, obstetric and perinatal outcomes are not yet well established and the effect of levothyroxine replacement in pregnant women with SH is unclear. The aim of this study was to evaluate the impact of thyroid autoimmunity in early pregnancy on obstetric and perinatal out...

Germinal mutations of the oncogene RET originate the development of medullary thyroid carcinoma (MTC) in carriers with phenotypic expression depending on the mutated codon and other unknown factors. Simultaneous detection of differentiated thyroid carcinomas is considered a casual phenomenon (collision tumours). We communicate two brothers with double heterozygous mutation of maternal inheritance at codon 611 of RET, TGC to TTT, changing to encode phenylalanine (C611F), with a...

Current guidelines suggest sonographic follow-up in thyroid nodules smaller than 10 mm with intermediate or highly suspicious features as ultrasound-guided FNAC has poor results in these nodules, and the risk of non-diagnosed thyroid carcinoma is very low. CNB has proved superior to repeated FNAC in case of insufficient or indeterminate first FNAC.Objective: Evaluate diagnostic accuracy of CNB in nodules smaller than 10 mm with intermediate or high suspi...

sTg is universally accepted as the best marker of disease status in DTC. Its presurgical serum level may suggest the presence of distant metastasis in case of very high level, but the correlation between its level and the characteristics of the tumour is yet to be defined.Objective: To evaluate preoperative thyroglobulin as predictor of DCT features.Methods: Preoperative sTg was measured in patients operated for DTC between 2011&#1...